Dimethyl Sulfoxide → tert-Butyl 4-cyano-4-(3-fluorophenyl)piperidine-1-carboxylate
Reaction equation
[CH3:27][S:28]([CH3:29])=[O:30].[Cl:11][CH2:12][CH2:13][N:14]([C:15]([O:16][C:17]([CH3:18])([CH3:19])[CH3:20])=[O:21])[CH2:22][CH2:23][Cl:24].[Cl:31][CH2:32][Cl:33].[F:1][c:2]1[cH:3][c:4]([CH2:8][C:9]#[N:10])[cH:5][cH:6][cH:7]1.[H-:25].[Na+:26]>>[F:1][c:2]1[cH:3][c:4]([C:8]2([C:9]#[N:10])[CH2:12][CH2:13][N:14]([C:15]([O:16][C:17]([CH3:18])([CH3:19])[CH3:20])=[O:21])[CH2:22][CH2:23]2)[cH:5][cH:6][cH:7]1Participants
7
Sources & evidence
- ORD record
- ord-fb50cc5166f94b3a9df5eeb3f172742b
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (1/10)
Reaction notes
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