Hydrazine, propyl- → HCID 54060269, compound

Participants

Reaction Steps

A mixture of 4.28g of tetrahydro-3,5-bis-[[3-(trifluoromethyl)phenyl]methylene]-4H-thiopyran-4-one and 962mg of n-propyl hydrazine in 150ml of methanol is heated at reflux temperature for 3 hours and then cooled to room temperature. Solids are collected and washed to give 1.3g of the title compound, melting point 90°-93.5°C. The combined mother liquor and washings are concentrated to 100ml and 15-20ml of water is added to the hot solution. Upon cooling, an additional 1.8g of material is collected and recrystallized from methanol/water to give 1.6g of the title compound, melting point 89°-93°C.

Provenance & Evidence