Sodium Hydroxide → 3-But-3-enylaminopropionaldehyde

But-3-enylamine (1.0 mole), the diethyl acetal of 3-bromopropionaldehyde (1.0 mole) and methanol (100 ml) are charged into a glass reaction vessel equipped with a mechanical stirrer, thermometer and reflux condenser. The reaction mixture is heated at reflux with stirring for a period of about 6 hours. After this time the reaction mixture is cooled to room temperature and sodium hydroxide (20 grams) is added. The reaction mixture is then stirred for an additional period of about 16 hours. The mixture is then filtered and the filtrate is distilled to yield the desired product the diethyl acetal of 3-but-3-enylaminopropionaldehyde.

1. customequipped with a mechanical stirrer
2. temperaturethermometer and reflux condenser
3. temperatureThe reaction mixture is heated
4. temperatureat reflux
5. stirringThe reaction mixture is then stirred for an additional period of about 16 hours
6. filtrationThe mixture is then filtered
7. distillationthe filtrate is distilled

ORD record

ord-a1f45ae4cc194cceb8992c684c598666

Source dataset

uspto-grants-1976_09

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US03979388