HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetone → Cimadronate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetone | HCID 180 | — |
| Reactant | Cyclohexylformamide | HCID 13017 | — |
| Reactant | Phosphorus trichloride | HCID 24387 | — |
| Reactant | Phosphorous acid | HCID 107909 | — |
| Solvent | Water | HCID 962 | — |
| Product | Cimadronate | HCID 405386 | 25% |
Reaction Steps
127.2 parts of N-cyclohexylformamide and 81 parts of phosphorous acid were reacted with 137.3 parts of phosphorus trichloride at 70°C, and maintained for 5 hours at this temperature. The reaction product was dissolved in water, treated with acetone and the precipitate separated. A 25% yield of N-cyclohexyl-1-aminomethane-1,1-diphosphonic acid, based on PCl3, was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03979385 |
| Source dataset | uspto-grants-1976_09 |
| ORD ID | ord-bfae2ae7ca024e7ab7ce950696b3cb16 |
| Source note | uspto-grants-1976_09 |