Hydrogen Sulfide → HCID 88833334, compound

Participants

Reaction Steps

A solution of benzhydryl 3-diazomethyl-7β-(2-thienylacetamido)-ceph-3-em-4-carboxylate (9.0 × 10-4 mole), prepared by the process described in Example 2, in 5 ml. dichloromethane solvent is stirred at room temperature while a slow stream of hydrogen sulfide gas is bubbled in. The excess gas and solvent is removed in vacuo and the residue chromatographed over silica gel with chloroform:acetone (10:1) to give benzhydryl 3-mercaptomethyl-7β-(2-thienylacetamido)-ceph-3-em-4-carboxylate.

Provenance & Evidence