Sodium Hydroxide → HCID 131710448, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 8.2 g (.022 mole) of 3-acetamido-4-carbomethoxy-2,5-dihydro-2-thiophenevaleric acid piperidide in 80 ml of methanol was added 40 ml of 1 N sodium hydroxide. The reaction was stirred at room temperature (22°C.) for 3 hrs. and was immediately worked up by first removing methanol under vacuum. The aqueous, basic residue was partitioned between 50 ml of water and 100 ml of methylene chloride. The basic, aqueous phase was extracted three times with 30 ml portions of methylene chloride. The methylene chloride was dried over sodium sulfate, filtered, and evaporated to afford 2.45 g (0.0075 mole, 34%) of 3-amino-4-carbomethoxy-2,5-dihydro-2-thiophenevaleric acid piperidide.

Provenance & Evidence