HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethanol → HCID 178470464, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethanol | HCID 702 | — |
| Reactant | Diphenyl Ether | HCID 7583 | — |
| Reactant | Diethyl {[(1-ethyl-1H-pyrazol-5-yl)amino]methylene}malonate | HCID 12845080 | — |
| Product | HCID 178470464 | HCID 178470464 | — |
Reaction Steps
253 g of [[(1-ethyl-5-pyrazolyl)amino]methylene]malonic acid diethyl ester (0.09 mol) is dissolved in 770 g of diphenyl ether. The reaction mixture is heated to 235°-250° (bath temperature) and allowed to react at this temperature for 1 to 2 hours, while the resulting ethanol is continuously distilled off. The remaining alcohol is removed by means of a water aspirator. The diphenyl ether is separated by distillation with a fractionating column in vacuo. The 1-ethyl-4-hydroxy-1H-pyrazolo[3,4-b]pyridinecarboxylic acid ethyl ester is obtained at b.p.0.05 115°-120°, yield 195 q = 92% of theory, m.p. 86°-87°. The compound is recrystallized from ligroin (90° to 100°), and has a melting point of 87°-89°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03979399 |
| Source dataset | uspto-grants-1976_09 |
| ORD ID | ord-9b75b29456244a9caaa27267f409632d |
| Source note | uspto-grants-1976_09 |