HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethanol → HCID 178469629, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethanol | HCID 702 | — |
| Reactant | [[[1-(2-Furyl)methyl-5-pyrazolyl]amino]methylene]malonic acid diethyl ester | HCID 68131587 | — |
| Solvent | Diphenyl Ether | HCID 7583 | — |
| Product | HCID 178469629 | HCID 178469629 | — |
Reaction Steps
250 g of [[[1-(2-furyl)methyl-5-pyrazolyl]amino]methylene]-malonic acid diethyl ester (0.75 mol) is dissolved in 1 liter of diphenyl ether and heated to 240° for 2 hours. The ethanol formed is continuously distilled off. The solvent is removed in vacuo. The 4-hydroxy-1-(2-furyl)methyl-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid ethyl ester remains and is recrystallized from methanol, yield 248 g (86%), m.p. 103°-106°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03979399 |
| Source dataset | uspto-grants-1976_09 |
| ORD ID | ord-f29425642d2443bba81b62e4c55c7ff5 |
| Source note | uspto-grants-1976_09 |