Sulfuryl chloride → HCID 21514365, compound

HRID 1576099Notes

Reaction equation

HRID 1576099 reaction equation
[C:1]1([C:7]([NH:9][C:10]2[NH:11][CH:12]=[CH:13][N:14]=2)=[S:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.S(Cl)([Cl:18])(=O)=O>C(Cl)(Cl)Cl>[ClH:18].[C:1]1([C:7]2[S:8][N:14]3[CH:13]=[CH:12][N:11]=[C:10]3[N:9]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

4

Reactant 2

HCID 24648Sulfuryl chlorideHCID 54451730HCID 54451730, compound

Product 1

HCID 21514365HCID 21514365, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent2×

Procedure

To a solution of 0.4 g. of 2-phenylthiocarbonylaminoimidazole [(IV), R = phenyl] in 20 ml. of chloroform there is added dropwise, at 20°-25°C., a solution of 0.165 ml. of sulfuryl chloride in 5 ml. of chloroform. After two hours the precipitate which forms is filtered, dissolved in methanol, and precipitated from ether to yield 2-phenyl-1,2,4-thiadiazolo-[2,3-a]-imidazole hydrochloride.

Workup

  1. filtrationAfter two hours the precipitate which forms is filtered
  2. dissolutiondissolved in methanol
  3. customprecipitated from ether

Sources & evidence

ORD record
ord-f55d7962f9e348e48fcbaa39d62b60d4
Source dataset
uspto-grants-1976_09
Patent number
US03979404

Reaction notes

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