HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethanol → 2-(3,4-Dicarbethoxy-2,5-dimethyl-pyrrol-1-yl)amino-4,5-dihydro-1H-imidazole hydrobromide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethanol | HCID 702 | — |
| Reactant | 1,4-Diethyl 2,3-diacetylbutanedioate | HCID 95399 | — |
| Reactant | 2-Hydrazino-delta-2-imidazoline hydrobromide | HCID 3085099 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | 2-(3,4-Dicarbethoxy-2,5-dimethyl-pyrrol-1-yl)amino-4,5-dihydro-1H-imidazole hydrobromide | HCID 13126145 | — |
Reaction Steps
To a solution of 15 g. (0.0581 mole) of diethyl 2,3-diacetylsuccinate in 150 ml. of absolute ethanol, 1.2 ml. of glacial acetic acid is added. The mixture is gently refluxed for 5 minutes then 8.13 g. (0.0467 mole) of 2-hydrazino-4,5-dihydro-1H-imidazole hydrobromide is added. The mixture is refluxed for 20 hours, then the solvent is evaporated off. The obtained residue is recrystallized several times from isopropanol, and 6.3 g. of the title compound are recovered. M.p. 172°-4°C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03979408 |
| Source dataset | uspto-grants-1976_09 |
| ORD ID | ord-0b7d0294b53349e0b66cb056dc3eec72 |
| Source note | uspto-grants-1976_09 |