2-Hydrazino-delta-2-imidazoline hydrobromide → 2-(3,4-Dicarbethoxy-2,5-diethyl-pyrrol-1-yl)amino-4,5-dihydro-1H-imidazole hydrobromide

HRID 1576105Notes

Reaction equation

HRID 1576105 reaction equation
[CH2:1]([O:3][C:4](=[O:20])[CH:5]([C:16](=O)[CH2:17][CH3:18])[CH:6]([C:12](=O)[CH2:13][CH3:14])[C:7]([O:9][CH2:10][CH3:11])=[O:8])[CH3:2].[BrH:21].[NH:22]([C:24]1[NH:25][CH2:26][CH2:27][N:28]=1)[NH2:23].C(O)(C)C.C(OCC)C>C(OCC)C>[BrH:21].[C:4]([C:5]1[C:6]([C:7]([O:9][CH2:10][CH3:11])=[O:8])=[C:12]([CH2:13][CH3:14])[N:23]([NH:22][C:24]2[NH:28][CH2:27][CH2:26][N:25]=2)[C:16]=1[CH2:17][CH3:18])([O:3][CH2:1][CH3:2])=[O:20]

Participants

5

Reactant 3

HCID 30850992-Hydrazino-delta-2-imidazoline hydrobromideHCID 13126143Diethyl 2,3-dipropanoylbutanedioateHCID 22147583Diethyl ether 2-propanol

Product 1

HCID 215144552-(3,4-Dicarbethoxy-2,5-diethyl-pyrrol-1-yl)amino-4,5-dihydro-1H-imidazole hydrobromide

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

The compound is obtained following substantially the method described in Example 3, by reacting 13 g. (0.0455 mole) of diethyl-2,3-dipropionyl-succinate with 8.14 g. (0.0449 mole) of 2-hydrazino-4,5-dihydro-1H-imidazole hydrobromide. Yield 55 g. M.p. 181°-2°C (from isopropanol/diethyl ether). The free base melts at 155°C (from diethyl ether).

Workup

  1. customThe compound is obtained

Sources & evidence

ORD record
ord-f06355498c94499ab7f87ebecc268bf3
Source dataset
uspto-grants-1976_09
Patent number
US03979408

Reaction notes

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