Dimethyl Sulfoxide → HCID 21514117, compound

Participants

Reaction Steps

A mixture of γ-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]-2,4-difluorobutyrophenone (3.94 g), 4-(p-chlorophenyl)-4-hydroxypiperidine (2.24 g) and dimethylsulfoxide (30 ml) was stirred at room temperature for 14 hours. The mixture was poured into 300 ml of water and extracted with ethyl acetate. The extract was washed with water, dried over anhydrous sodium sulfate and concentrated under reduced pressure. The residue was recrystallized from ethanol to yield γ,4-bis-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]-2-fluorobutyrophenone. M.P. 190° - 193°C.

Provenance & Evidence