Methanol → Methyl 7-methyl-9H-xanthene-2-carboxylate

HRID 1576135Notes

Reaction equation

HRID 1576135 reaction equation
[CH3:1][C:2]1[CH:15]=[C:14]2[C:5]([O:6][C:7]3[CH:8]=[CH:9][C:10]([C:16]([OH:18])=[O:17])=[CH:11][C:12]=3[CH2:13]2)=[CH:4][CH:3]=1.[CH3:19]O.S(=O)(=O)(O)O>O>[CH3:1][C:2]1[CH:15]=[C:14]2[C:5]([O:6][C:7]3[CH:8]=[CH:9][C:10]([C:16]([O:18][CH3:19])=[O:17])=[CH:11][C:12]=3[CH2:13]2)=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 887MethanolHCID 1118Sulfuric AcidHCID 215006717-Methyl-9H-xanthene-2-carboxylic acid

Product 1

HCID 21500836Methyl 7-methyl-9H-xanthene-2-carboxylate

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Twenty-six grams of 7-methylxanthene-2-carboxylic acid is added to 400 ml. of absolute methanol. To the resultant solution are added 18 ml. of concentrated sulfuric acid and the mixture is then heated at reflux for about two hours. The mixture is then cooled to 40° and sufficient water is added to bring the total volume to 1400 ml. The resultant mixture is then filtered to give methyl 7-methylxanthene-2-carboxylate.

Workup

  1. temperatureat reflux for about two hours
  2. temperatureThe mixture is then cooled to 40°
  3. filtrationThe resultant mixture is then filtered

Sources & evidence

ORD record
ord-e517ac80cacc4e97bfa952cb8d6313b0
Source dataset
uspto-grants-1976_09
Patent number
US03979414

Reaction notes

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