反应详情

To a suspension of 4 g. of dibutyl methylphosphonate in 75 ml. of dry monoglyme at about -78° under nitrogen, there is added with stirring one equivalent of n-butyl lithium in hexane. After about 10 minutes, there is added one equivalent of 17β-acetoxy-4-oxa-androst-5-en-3-one in 75 ml. of dry tetrahydrofuran while maintaining the temperature at about -78°. The reaction mixture is allowed to warm to room temperature and then left to stand for about four hours. The reaction mixture is diluted with water and extracted with ether. The ether extracts are combined, washed, dried and evaporated to give testosterone acetate (17β-acetoxyandrost-4-en-3-one) which can be purified by chromatography.

1. additionTo a suspension of 4 g
2. waitleft
3. waitto stand for about four hours
4. extractionextracted with ether
5. washwashed
6. customdried
7. customevaporated