HCID 68137148, compound → Estra-1,3,5(10),8-tetraen-17-one, 3-methoxy-

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Reaction Steps

0.5 g. of 3-methoxy-14α-estra-1,3,5(10), 8,15-pentaen-17-one in 25 ml. of ethanol is reduced catalytically with 50 mg. of 5% palladium-on-charcoal until a molar equivalent of hydrogen is taken up. The catalyst is filtered off and the filtrate evaporated to dryness to yield the known 3-methoxyestra-1,3,5 (10),8-tetraen-17-one which can be converted into estrone methyl ether by procedures outlined in Chemistry & Industry (London), 1022 (1960) or into 19-nor-Δ4 -steroids using the procedure of, for example, U.S. Pat. No. 3,318,922.

Provenance & Evidence