HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrazine hydrate (1:1) → HCID 68498053, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrazine hydrate (1:1) | HCID 24654 | — |
| Reactant | Dimethylformamide dimethyl acetal | HCID 78373 | — |
| Reactant | 1-(4-Chlorophenylsulfonyl)-2-(pyrimidin-5-yl)piperidin-4-one | HCID 59342391 | — |
| Reactant | HCID 68500265 | HCID 68500265 | — |
| Product | HCID 68498053 | HCID 68498053 | — |
Reaction Steps
trans-1-(4-Chlorophenylsulfonyl)-2,6-dimethylpiperidin-4-one (94) was treated with DMF-DMA followed by hydrazine hydrate as described for compound 71 in Example 4. 1H-NMR (CD3OD) δ 7.81-7.79 (m, 2H), 7.62 (m, 3H), 5.38 (q, J=7.1 Hz, 1H), 4.20-4.13, (m, 1H), 2.78 (dd, J=16.2, 4.4 Hz, 1H), 2.56-2.48 (m, 1H), 1.54-1.47 (m, 6H); MS (m/z) 326.0 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07732609B2 |
| Source dataset | uspto-grants-2010_06 |
| ORD ID | ord-29229ebb900347458e26b79b02416943 |
| Source note | uspto-grants-2010_06 |