Methyl iodide → 5,6-Bis(4-fluorophenyl)-3-(methylsulfanyl)-1,2,4-triazine

HRID 1576235Notes

Reaction equation

HRID 1576235 reaction equation
[SH:1][C:2]1[N:3]=[N:4][C:5]([C:15]2[CH:20]=[CH:19][C:18]([F:21])=[CH:17][CH:16]=2)=[C:6]([C:8]2[CH:13]=[CH:12][C:11]([F:14])=[CH:10][CH:9]=2)[N:7]=1.[CH3:22]I.[OH-].[Na+]>C(O)C>[CH3:22][S:1][C:2]1[N:3]=[N:4][C:5]([C:15]2[CH:20]=[CH:19][C:18]([F:21])=[CH:17][CH:16]=2)=[C:6]([C:8]2[CH:9]=[CH:10][C:11]([F:14])=[CH:12][CH:13]=2)[N:7]=1

Participants

5

Reactant 3

HCID 6328Methyl iodideHCID 14798Sodium HydroxideHCID 178505578HCID 178505578, compound

Product 1

HCID 155716015,6-Bis(4-fluorophenyl)-3-(methylsulfanyl)-1,2,4-triazine

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

3-Mercapto-5,6-bis(4-fluorophenyl)-1,2,4-triazine, 16.6 g. (0.05 mole), was reacted with 7 g. (0.05 mole) of methyl iodide in 75 ml. of ethanol containing 2 g. (0.05 mole) of sodium hydroxide by the method of Example 4(B). The yield was 13.2 g. of 3-methylthio-5,6-bis(4-fluorophenyl)-1,2,4-triazine, mp about 132°-135°C., after crystallization from ethanol.

Workup

  1. custom(0.05 mole), was reacted with 7 g
  2. customof 3-methylthio-5,6-bis(4-fluorophenyl)-1,2,4-triazine, mp about 132°-135°C., after crystallization from ethanol

Sources & evidence

ORD record
ord-947fc0f2684f440d8b488239397bcb34
Source dataset
uspto-grants-1976_09
Patent number
US03979516

Reaction notes

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