Methanol → 4-(Benzyloxy)-3,5-diphenyl-1H-pyrazole

Participants

Reaction Conditions

Reaction Steps

A mixture of 3,5-diphenyl-4-pyrazolol (10 g, 0.042 mole), sodium methoxide (2.27 g, 0.042 mole) and methanol (60 ml) is heated at 60°C for 2 hours. Benzyl chloride (5.33 g, 0.042 mole) is then added slowly (10 minutes) at 60°C. A white solid forms. Heating is continued overnight at 60°C. The reaction mixture is then examined by glc and found to be complete. The mixture is poured into water and the solid isolated by filtration. The solid is washed well with water and dried to yield 12.84 g (94%) product.

Provenance & Evidence