Aluminum isopropoxide → HCID 18740730, compound

Participants

Reaction Conditions

Reaction Steps

10-Hydroxy-1'-methyl-9,10-dihydroanthracene-9-spiro-4'-piperidine (whose preparation is described in Example 2) (1 g.) and aluminium isopropoxide (3.1 g.) are thoroughly mixed and heated to 220°C. When acetone ceases to distil off the reaction mixture is heated to 225°C. for 40 minutes and then allowed to cool. Concentrated hydrochloric acid (7 ml.) in water (10 ml.) is added and the mixture is stirred for 30 minutes, basified with 2N sodium hydroxide and extracted with ethyl acetate. The organic layer is dried (Na2SO4) and evaporated to give a gum which crystallises on trituration with ether and is recrystallised twice from ether-petroleum ether (b.p. 40°- 60°C.) to give 1'-methyl-9,10-dihydroanthracene-9-spiro-4'-piperidine m.p. 132°-134°C.

Provenance & Evidence