Citric Acid → HCID 86733948, compound

Participants

Reaction Steps

4-Hydroxy-1'-methyl-9,10-dihydroanthracene-9-spiro-4'-piperidine (0.9 g.) is added to pyridine (7 ml.) and acetic anhydride (5 ml.) and the solution is warmed on the steam bath for 1 hour. It is then poured into water, basified with solid sodium carbonate, and extracted with ethyl acetate. The ethyl acetate extract is washed with water, dried (MgSO4), and evaporated to give an oil to which is added an excess of a saturated solution of citric acid in ether. The resulting solid is filtered off and recrystallised three times from methanol-ether to give 4-acetoxy-1'-methyl-9,10-dihydroanthracene-9-spiro-4'-piperidine citrate m.p. 156°-159°C.

Provenance & Evidence