4-Aminothiophenol → HCID 21511729, compound

Participants

Reaction Steps

A 1-liter 3-neck flask equipped with stirrer, condenser, heating mantle, addition funnel and thermometer is charged with 25 g (0.2 mole) of 4-aminothiophenol, 26.4 g (0.2 mole) of 2,5-dimethoxytetrahydrofuran, and 150 ml of glacial acetic acid. The reaction mass is refluxed for 30 minutes, cooled and made alkaline to a pH of 9 with 130 ml of 50% aqueous sodium hydroxide while maintaining the temperature of the reaction mixture below 25°C with a cooling bath.

Provenance & Evidence