反应详情

温度

80 °C

After adding 30 ml of benzene to the potassium pyrrole, a solution of 30.0 g (0.22 mole) of ethylchloropropionate in 30 ml benzene is slowly added to the paste over a period of 1 hour with constant stirring. The reaction mixture is heated to 80°C for 30 minutes. Then 100 ml of water is added and the mixture is extracted with diethyl ether. The ether extract is dried over anhydrous magnesium sulfate and the dried extract is evaporated to yield residue which is distilled under vacuum. The pyrrole derivative having the formula given above is obtained as 3 g of a colorless liquid with a boiling point of 108°C at 14 mm Hg pressure. MS shows the m/e peaks: 80, 94, 167, 27, 95.

1. extractionthe mixture is extracted with diethyl ether
2. extractionThe ether extract
3. dry with materialis dried over anhydrous magnesium sulfate
4. extractionthe dried extract
5. customis evaporated
6. customto yield residue which
7. distillationis distilled under vacuum