Phosphate → L-Malic Acid

HRID 1576281Notes

Reaction equation

[C:1]([OH:8])(=[O:7])/[CH:2]=[CH:3]/[C:4]([OH:6])=[O:5].P([O-])([O-])([O-])=[O:10]>>[C:1]([OH:8])(=[O:7])[C@H:2]([CH2:3][C:4]([OH:6])=[O:5])[OH:10]

Participants

Reactant 2

HCID 1061Phosphate

HCID 444972Fumaric Acid2×

Product 1

HCID 222656L-Malic AcidYield 76%

Conditions

Temperature: 20 °C

Procedure

These 2 ml were added to 100 ml of phosphate buffer, pH of 7.0, containing 0.05 mole of fumaric acid (neutralized by sodium hydroxide). The reaction mixture was stirred at 20°C. After 11 hours, 1.39 g of fumaric acid remained and 5.05 g of L-malic acid were formed corresponding to a 76% yield.

Sources & evidence

ORD record: ord-7a8e0d98ada14e2caab3e543fd09ffc7
Source dataset: uspto-grants-1976_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US03980520

Reaction notes

Loading…