HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tris(2-chloroethyl) phosphite → {[Methyl(methylcarbamoyl)amino]methyl}phosphonic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tris(2-chloroethyl) phosphite | HCID 8783 | — |
| Reactant | HCID 21501243 | HCID 21501243 | — |
| Solvent | Acetic acid--water (1/1) | HCID 21899381 | — |
| Product | {[Methyl(methylcarbamoyl)amino]methyl}phosphonic acid | HCID 21718273 | — |
Reaction Steps
This phosphonic acid is prepared in a similar manner using tris(2-chloroethyl) phosphite as the phosphorus ester reactant. The crude intermediate 1,4-dimethyl-2-(2-chloroethoxy)-1,4,2-diazaphospholidin-5-one-2-oxide (31P nmr -24.9 ppm) is hydrolyzed without isolation from the reaction mixture to give the acid: mp 171°-172° dec. (acetic acid-water).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03980618 |
| Source dataset | uspto-grants-1976_09 |
| ORD ID | ord-7b6cf517aed540d995728e0e8fb0bbcb |
| Source note | uspto-grants-1976_09 |