1,3-Propanediamine → HCID 21511922, compound

HRID 1576316Notes

Reaction equation

HRID 1576316 reaction equation
ClC(Cl)(Cl)[C:3]([NH:5][C:6]1[CH:19]=[CH:18][C:17]([Cl:20])=[CH:16][C:7]=1[C:8]([C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)=O)=[O:4].[NH2:23][CH2:24][CH2:25][CH2:26][NH2:27].O>C(O)C>[Cl:20][C:17]1[CH:18]=[CH:19][C:6]2[NH:5][C:3](=[O:4])[N:23]3[CH2:24][CH2:25][CH2:26][NH:27][C:8]3([C:10]3[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=3)[C:7]=2[CH:16]=1

Participants

5

Reactant 3

HCID 4281,3-PropanediamineHCID 962WaterHCID 306974STK173631

Product 1

HCID 21511922HCID 21511922, compoundYield 79.5%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of 1.89 g of 2-trichloroacetamido-5-chlorobenzophenone in 50 ml of ethanol was added 2.22 g of 1,3-diaminopropane, and the resultant mixture was allowed to stand at room temperature overnight. Then, the reaction mixture was poured into 300 ml of water, and the precipitate thus formed was separated by filtration, washed with ether and dried to give 1.25 g of 10-chloro-1,2,3,4,7,11b-hexahydro-11b-phenyl-6H-pyrimido[1,2-C]quinazolin-6-one, having a melting point of 275° - 276°C.

Workup

  1. customthe precipitate thus formed
  2. customwas separated by filtration
  3. washwashed with ether
  4. customdried

Sources & evidence

ORD record
ord-8c7287ff63484887b9ae3b07a10adfc0
Source dataset
uspto-grants-1976_09
Patent number
US03980645

Reaction notes

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