Bis(Chloromethyl) Ether → HCID 86733979, compound

HRID 1576332Notes

Reaction equation

HRID 1576332 reaction equation
[CH:1]1([CH2:5][N:6]2[CH2:23][CH2:22][C@@:13]34[C:14]5[CH:15]=[C:16]([OH:21])[CH:17]=[CH:18][C:19]=5[CH2:20][C@@H:7]2[C@:8]3([OH:24])[CH2:9][CH2:10][CH2:11][CH2:12]4)[CH2:4][CH2:3][CH2:2]1.C[O-].[Na+].Cl[CH2:29][O:30][CH2:31]Cl>C1C=CC=CC=1>[CH:1]1([CH2:5][N:6]2[CH2:23][CH2:22][C@@:13]34[C:14]5[CH:15]=[C:16]([O:21][CH2:29][O:30][CH3:31])[CH:17]=[CH:18][C:19]=5[CH2:20][C@@H:7]2[C@:8]3([OH:24])[CH2:9][CH2:10][CH2:11][CH2:12]4)[CH2:4][CH2:3][CH2:2]1

Participants

5

Reactant 3

HCID 10967Bis(Chloromethyl) EtherHCID 5361092ButorphanolHCID 10942334Sodium Methoxide

Product 1

HCID 86733979HCID 86733979, compound

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

One mole of compound XXVII was placed in 3 liters of benzene. One mole of sodium methoxide was added, followed by the slow addition of 1 mole of chloromethyl ether with stirring. The solution was heated to reflux to yield the title product.

Workup

  1. temperatureThe solution was heated
  2. temperatureto reflux

Sources & evidence

ORD record
ord-cef80513364c429fb2409d387d1c9b65
Source dataset
uspto-grants-1976_09
Patent number
US03980641

Reaction notes

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