Indole → HCID 21512049, compound

Participants

Reaction Steps

A starting compound of the formula II may also be obtained by reacting an indole of the formula IV in a mixture of glacial acetic acid and phosphoric acid with the equivalent quantity of N-acetyl-4-piperidone, preferably at room temperature. The corresponding 4-indolyl-1-acetyl-1,2,5,6-tetrahydropyridine is thus obtained, which is then hydrogenated in conventional manner in the presence of palladium/coal at room temperature and atmospheric pressure to form the corresponding piperidine derivative; the latter is subsequently hydrolized in a mixture of a lower alkanol and aqueous 50% potassium hydroxide.

Provenance & Evidence