Ammonia → HCID 21389739, compound

Participants

Reaction Conditions

Reaction Steps

50 ml of 85 % polyphosphoric acid and 50 g of phosphorus pentoxide were mixed and 0.1 mole of 1-cyano-1-phenyl-3-(1-methyl-piperazine-4-yl)-propane was added. The reaction mixture was heated to 80°C and 0.04 mole of 4-chlorobenzaldehyde was added. The whole was heated for 1 hour to 100°C and 0.04 mole of 4-chlorobenzaldehyde was added. After a further hour at 100°C the mixture was poured into 1 liter of water and the pH value was adjusted to 10 by means of concentrated ammonia. The crystal magma was filtered off with suction and recrystallized from ethanol. M.p.: 201°-205°C (oxalate)

Provenance & Evidence