HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetone → 2,2,5,5-Tetramethyl-1,3-thiazolidine-4-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetone | HCID 180 | — |
| Reactant | dl-Valine, 3-mercapto-, hydrochloride | HCID 12278514 | — |
| Product | 2,2,5,5-Tetramethyl-1,3-thiazolidine-4-carboxylic acid | HCID 93964 | — |
Reaction Steps
Ninety-three grams (0.5 mole) of D,L-penicillamine hydrochloride in 500 ml of acetone were heated at reflux temperature for 30 minutes under a nitrogen atmosphere. After distilling off the excess acetone there were obtained 113 grams of D,L-2,2,5,5-tetramethyl-thiazolidine-4-carboxylic acid. The yield amounts to 99%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03980666 |
| Source dataset | uspto-grants-1976_09 |
| ORD ID | ord-d3810b3d329845aaab5dab9d9c145918 |
| Source note | uspto-grants-1976_09 |