Estrone → HCID 9802454, compound

Participants

Reaction Steps

Oestrone (2 g., 7.4 mmole) in pyridine (10 ml.) was treated at room temperature for 3 days with toluene-p-sulphonyl chloride (2 g., 1.4 equiv.). The stirred mixture was slowly diluted with water (40 ml.). The precipitated oil slowly crystallized on agitation. Recrystallisation from methanol -- methylene cloride gave the title compound plates (2.65 g., 85%), m.p. 143°-145° , [α]D + 105°. (c, 1.00).

Provenance & Evidence