Potassium Hydroxide → HCID 21512538, compound

Participants

Reaction Steps

The above prepared 1-(9-xanthenyl)-3-(N-carbethoxy-N-methylamino)piperidine (4.5 g.) is refluxed with 100 ml. of a 5M solution of potassium hydroxide in 80 percent aqueous ethanol for three hours. The resulting solution is concentrated in vacuo and the residue poured into cold water. This mixture is extracted with methylene chloride and the organic phase is washed with water and dried over anhydrous potassium carbonate. Evaporation of the solvent gives 1-(9-xanthenyl)-3-methylaminopiperidine.

Provenance & Evidence