3-(4'-Fluoro-4-biphenylyl)-3-hydroxybutyric acid hydrazide → 3-(4'-Fluoro-4-biphenylyl)-3-methyl-pyrazolidin-5-one

Participants

Reaction Steps

28.8 g of 3-(4'-fluoro-4-biphenylyl)-3-hydroxybutyric acid hydrazide [obtainable by Friedel-Crafts acetylation of 4-fluorobiphenyl to give 4-p-fluorophenylacetophenone, reaction with bromoacetic acid ethyl ester/zinc to give 3-(4'-fluoro-4-biphenylyl)-3-hydroxybutyric acid ethyl ester and reaction with hydrazine hydrate in ethanol] in 200 ml of DMF is heated and worked up in the customary manner to give 3-(4'-fluoro-4-biphenylyl)-3-methyl-pyrazolidin-5-one, m.p. 194°-196°.

Provenance & Evidence