HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → 3-(4'-Fluoro-4-biphenylyl)-3-methyl-pyrazolidin-5-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | Hydrazine Sulfate | HCID 24842 | — |
| Reactant | Sodium ethoxide | HCID 2723922 | — |
| Reactant | 3-Chloro-3-(4'-fluoro-4-biphenylyl)-butyric acid ethyl ester | HCID 54062559 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 3-(4'-Fluoro-4-biphenylyl)-3-methyl-pyrazolidin-5-one | HCID 21512675 | — |
Reaction Steps
A solution of 32.1 g of 3-chloro-3-(4'-fluoro-4-biphenylyl)-butyric acid ethyl ester (obtainable from the hydroxy ester and SOCl2), 15 g of hydrazine sulfate and 20.5 g of sodium ethylate in 500 ml of absolute ethanol is boiled for 2 hours and the solvent is evaporated. Working up gives 3-(4'-fluoro-4-biphenylyl)-3-methyl-pyrazolidin-5-one, m.p. 194°-196°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03980795 |
| Source dataset | uspto-grants-1976_09 |
| ORD ID | ord-e3dca0e911084cf5913ae87adfc6c05c |
| Source note | uspto-grants-1976_09 |