HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrazine hydrate (1:1) → 3-(4'-Fluoro-4-biphenylyl)-3-methyl-pyrazolidin-5-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrazine hydrate (1:1) | HCID 24654 | — |
| Reactant | 3-(4'-Fluoro-4-biphenylyl)-2-butenoic acid ethyl ester | HCID 57064292 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 3-(4'-Fluoro-4-biphenylyl)-3-methyl-pyrazolidin-5-one | HCID 21512675 | — |
Reaction Steps
A solution of 28.4 g of 3-(4'-fluoro-4-biphenylyl)-2-butenoic acid ethyl ester [obtainable by dehydrating 3-(4'-fluoro-4-biphenylyl)-3-hydroxybutyric acid ethyl ester employing p-toluenesulfonic acid] and 25 g of hydrazine hydrate (100% strength) in 400 ml of ethanol is boiled for 18 hours. The mixture is cooled, poured onto ice water and worked up in the usual manner to give 3-(4'-fluoro-4-biphenylyl)-3-methyl-pyrazolidin-5-one, m.p. 194°-196°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03980795 |
| Source dataset | uspto-grants-1976_09 |
| ORD ID | ord-8e960e644d0b464eaab7e60915290631 |
| Source note | uspto-grants-1976_09 |