HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 3-(4'-Fluoro-4-biphenylyl)-3-methyl-pyrazolidin-5-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 4-Bromo-4'-fluoro-1,1'-biphenyl | HCID 96882 | — |
| Reactant | 3H-Pyrazol-3-one, 2,4-dihydro-5-methyl- | HCID 319771 | — |
| Reactant | Magnesium | HCID 5462224 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 3-(4'-Fluoro-4-biphenylyl)-3-methyl-pyrazolidin-5-one | HCID 21512675 | — |
Reaction Steps
A solution of 9.8 g of 3-methyl-pyrazolin-5-one in 100 ml of THF is added dropwise with stirring and cooling, to a Grignard solution prepared from 4.8 g of magnesium and 20.3 g of 4-bromo-4'-fluoro-biphenyl in 800 ml of absolute ether. After stirring for 2 hours at 10°-25°, the mixture is decomposed with ice and dilute hydrochloric acid and worked up in the usual manner to give 3-(4'-fluoro-4-biphenylyl)-3-methyl-pyrazolidin-5-one, m.p. 194°-196°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03980795 |
| Source dataset | uspto-grants-1976_09 |
| ORD ID | ord-273526f54ead4027bf8c38140a4f142b |
| Source note | uspto-grants-1976_09 |