Sodium Carbonate → HCID 21510699, compound

HRID 1576478Notes

Reaction equation

HRID 1576478 reaction equation
[NH:1]1[CH2:5][CH2:4][CH:3]([OH:6])[CH2:2]1.C(=O)([O-])[O-].[Na+].[Na+].[CH:13]1[CH:18]=[C:17]2[C:19]([C:22]([C:24](Cl)=[O:25])=[O:23])=[CH:20][NH:21][C:16]2=[CH:15][CH:14]=1>O>[NH:21]1[C:16]2[C:17](=[CH:18][CH:13]=[CH:14][CH:15]=2)[C:19]([C:22](=[O:23])[C:24]([N:1]2[CH2:5][CH2:4][CH:3]([OH:6])[CH2:2]2)=[O:25])=[CH:20]1

Participants

5

Reactant 3

HCID 10340Sodium CarbonateHCID 899523-Indoleglyoxylyl chlorideHCID 982104-Hydroxypyrrolidine

Product 1

HCID 21510699HCID 21510699, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

--A solution of 1.25 g. (0.014 mole) of 3-pyrrolidinol and 3.0 g. of sodium carbonate in 35 ml. of water was treated all at once with 3 g. (0.014 mole) of indole-3-glyoxyloyl chloride and the mixture stirred at room temperature for 24 hours. The product was isolated by filtration and recrystallized from absolute alcohol. The yield was 2.6 g. (70%) and the material melted at 216°-218° C.

Workup

  1. customThe product was isolated by filtration
  2. customrecrystallized from absolute alcohol

Sources & evidence

ORD record
ord-d25c3726c3c14bfbaf581c9379df38c9
Source dataset
uspto-grants-1976_09
Patent number
USRE028973

Reaction notes

Loading…