Chloroform → HCID 54034944, compound

HRID 1576480Notes

Reaction equation

HRID 1576480 reaction equation
[CH3:1][C:2]1[NH:3][C:4]2[C:9]([C:10]=1[CH2:11][CH2:12][N:13]1[CH2:17][CH2:16][CH:15]([OH:18])[CH2:14]1)=[CH:8][CH:7]=[CH:6][CH:5]=2.C(=O)([O-])[O-].[Na+].[Na+].C(Cl)(Cl)Cl.[CH3:29][O:30][C:31]1[CH:32]=[C:33]([CH:37]=[C:38]([O:42][CH3:43])[C:39]=1[O:40][CH3:41])[C:34](Cl)=[O:35]>O>[CH3:1][C:2]1[NH:3][C:4]2[C:9]([C:10]=1[CH2:11][CH2:12][N:13]1[CH2:17][CH2:16][CH:15]([O:18][C:34](=[O:35])[C:33]3[CH:32]=[C:31]([O:30][CH3:29])[C:39]([O:40][CH3:41])=[C:38]([O:42][CH3:43])[CH:37]=3)[CH2:14]1)=[CH:8][CH:7]=[CH:6][CH:5]=2

Participants

6

Reactant 4

HCID 6212Chloroform2×HCID 10340Sodium CarbonateHCID 78282Benzoyl chloride, 3,4,5-trimethoxy-HCID 21510688HCID 21510688, compound

Product 1

HCID 54034944HCID 54034944, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

To a suspension of 5 g. (0.02 mole) of 2-methyl-3-[2-(3-hydroxypyrrolidinyl)ethyl]indole and 8 g. (0.075 mole) of sodium carbonate in 40 ml. of chloroform was added 4.2 g. (0.018 mole) of 3,4,5-trimethoxybenzoyl chloride in 30 ml. of chloroform. The mixture was stirred under anhydrous conditions for 24 hours, then treated with 25 ml. of water and stirred an additional hour. The chloroform layer was separated, dried over magnesium sulfate and evaporated on a rotating evaporator to a viscous oil.

Workup

  1. additionTo a suspension of 5 g
  2. additiontreated with 25 ml
  3. customThe chloroform layer was separated
  4. dry with materialdried over magnesium sulfate
  5. customevaporated on a rotating evaporator to a viscous oil

Sources & evidence

ORD record
ord-0843ed06b7f749bb82ba1eadb0ec417f
Source dataset
uspto-grants-1976_09
Patent number
USRE028973

Reaction notes

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