Hydrochloric Acid → 3-Butyl-5-chloro-6-(trifluoromethyl)-2,4(1H,3H)-pyrimidinedione

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Reaction Steps

3-n-butyl-6-(trifluoromethyl)uracil (1.0 g.) was dissolved in 15 ml. of 5.25% sodium hypochlorite solution and allowed to stand at room temperature for 1 hour. The suspension which was present was acidified to pH 1 with hydrochloric acid and the solid removed by filtration. After purification by chromatography and recrystallization from cyclohexane, the product had a melting point of 138°-139°C.

Provenance & Evidence