2-Aminobenzimidazole → HCID 12429110, compound

Participants

Reaction Steps

o-Bromo-α-chloroanisole 15.0 g (0.0679 mol) in 20 ml of sulfolane is added to a solution of 4.50 g (0.0339 mol) of 2-aminobenzimidazole in 40 ml of sulfolane. The mixture turns into a semi-solid mass upon standing for several hours. After standing for 6.75 days at room temperature, the reaction mixture is diluted with 40 ml of 2-propanol, filtered, and the product is washed with 2-propanol. Trituration with ether gives 7.7 g (43%) of a white solid; mp 229°-230°. Recrystallization of 3.5 g of this material from 340 ml of 90% ethanol gives 2.5 g of the named product as a white fluffy solid after drying for 6 hours at 78° (1 mm): mp 236°-237°dec.

Provenance & Evidence