Potassium Hydroxide → HCID 21511432, compound

Participants

Reaction Steps

Potassium hydroxide (3.4 g.) was fused at 180°C. with water (1 ml.), and 2,4-difluorophenol (5.2 g.) added. 2-(4-Iodophenyl)propionic acid (5.5 g.) and copper bronze (0.2 g.) were then added to the melt, and the resulting mixture was stirred at 160°-170°C. for 2 hours. The cooled solid was extracted with methylene chloride containing a little dilute hydrochloric acid, filtered, and the solution extracted with dilute potassium carbonate solution. The aqueous extract was washed with ether and acidified with dilute hydrochloric acid; the resulting oil was isolated in ether and evaporated to dryness. The resulting solid was purified by preparative layer chromatography using 5% acetic acid/petroleum ether b.p. 62°-68°C. and eluting with ethyl acetate; recrystallization from petroleum ether b.p. 80°-100°C. gave 2-[4-(2,4-difluorophenoxy)phenyl] propionic acid, m.p. 105°-106°C.

Provenance & Evidence