反应详情

A solution of 5-(3-aminopropyl)-5H-dibenzo[a,d]cycloheptene (0.75 g., 0.003 mole) in 5 ml. of dry pyridine is treated with 1 ml. of acetic anhydride and then heated to refluxing for 30 minutes. The cooled solution is poured into 100 ml. of water and the oil extracted into benzene. The benzene extract is washed with water, 3N hydrochloric acid, water, and evaporated to dryness under reduced pressure. The 5-(3-acetamidopropyl)-5H-dibenzo[a,d]cycloheptene is obtained as a yellow oily residue weighing 0.87 g.

1. temperatureto refluxing for 30 minutes
2. additionThe cooled solution is poured into 100 ml
3. extractionof water and the oil extracted into benzene
4. extractionThe benzene extract
5. washis washed with water, 3N hydrochloric acid, water
6. customevaporated to dryness under reduced pressure