2-Oxoglutaric Acid → HCID 86734016, compound

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Reaction Steps

12 g. (0.082 mole) of 2-ketoglutaric acid are dissolved in 500 ml. of methanol. The solution is brought to the boil and 22.5 g. (0.0635 mole) of vincamine are added a small amount at a time, with vigorous agitation. When dissolution is complete, the resulting solution is concentrated in a rotary evaporator until its volume is reduced to 200 ml. On cooling, 22 g. of vincamine 2-ketoglutarate are obtained. By adding 500 ml. of ethyl ether to the mother liquors, a further amount of 9.6 g. of the salt are obtained. The total amount of salt obtained is therefore, 29.6 g. (yield 93%). The melting point is 214°-215°C.

Provenance & Evidence