2-Oxoglutaric Acid → HCID 86734016, compound

Participants

Reaction Steps

650 ml. of vincamine hydrochloride (1.66 millimole) are dissolved in 10 ml. of water, and, after vibration, a solution of 248 mg. (1.73 millimole) of 2-ketoglutaric acid and 145 mg. of sodium bicarbonate in 3 ml. of water is added. After being allowed to stand and cool, 453 mg. of vincamine 2-ketoglutarate are obtained. The resulting solution is concentrated in a rotary evaporator to one third of the original volume and, after cooling, an additional amount of 287 mg. of salt are obtained. A total of 740 mg. of salt is thus obtained, that is to say, a yield of 89%.

Provenance & Evidence