2-Oxoglutaric Acid → HCID 86734016, compound

HRID 1576655Notes

Reaction equation

HRID 1576655 reaction equation
[CH3:1][CH2:2][C@:3]12[CH2:19][C@:18]([OH:24])([C:20]([O:22][CH3:23])=[O:21])[N:17]3[C:9]4=[C:10]([CH2:25][CH2:26][N:7]([C@@H:8]14)[CH2:6][CH2:5][CH2:4]2)[C:11]1[CH:12]=[CH:13][CH:14]=[CH:15][C:16]=13.C(Cl)(Cl)Cl.[O:31]=[C:32]([CH2:36][CH2:37][C:38]([OH:40])=[O:39])[C:33]([OH:35])=[O:34]>CO>[CH3:1][CH2:2][C@:3]12[CH2:19][C@:18]([OH:24])([C:20]([O:22][CH3:23])=[O:21])[N:17]3[C:9]4=[C:10]([CH2:25][CH2:26][N:7]([C@@H:8]14)[CH2:6][CH2:5][CH2:4]2)[C:11]1[CH:12]=[CH:13][CH:14]=[CH:15][C:16]=13.[O:31]=[C:32]([CH2:36][CH2:37][C:38]([O-:40])=[O:39])[C:33]([O-:35])=[O:34]

Participants

5

Reactant 3

HCID 512-Oxoglutaric AcidHCID 6212ChloroformHCID 15376Vincamine

Product 1

HCID 86734016HCID 86734016, compoundYield 90%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

1.617 g. of vincamine (0.005 mole) is dissolved in 15 ml. of chloroform, and 0.8 g. (0.055 mole) of 2-ketoglutaric acid previously dissolved in 5 ml. of methanol is added. After concentration of the resulting solution in a rotary evaporator until a volume of 5 ml. is obtained, 1.75 g. of vincamine 2-ketoglutarate is obtained. By subsequent successive concentrations, an additional amount of 0.5 g. of salt is obtained. A total of 2.25 g. is thus obtained (yield 90%).

Workup

  1. customAfter concentration of the resulting solution in a rotary evaporator until a volume of 5 ml
  2. customis obtained

Sources & evidence

ORD record
ord-db401e945ab1495dac17653a13ee6c02
Source dataset
uspto-grants-1976_09
Patent number
US03982002

Reaction notes

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