1-Bromo-3,4-(methylenedioxy)benzene → HCID 178419615, compound

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Reaction Steps

1.35 g. magnesium chips and 20 ml. tetrahydrofuran are added in a nitrogen atmosphere to a flask provided with a stirrer, a drip funnel, a thermometer and a reflux condenser and a potassium hydroxide drying tube. The whole is then heated to 50° - 60°C and a few drops of bromine and a few drops of a solution of 11 g. 3.4-methylene dioxybromo-benzene in 50 ml. tetrahydrofuran are added. When the reaction has started, the remainder of the methylene dioxy bromo-benzene solution in tetrahydrofuran is added drop by drop for approximately 10 minutes and the resultant mixture is then left to react for 1 hour at 50° - 60°C. The Grignard solution obtained is used immediately for the reaction described below:

Provenance & Evidence