Isopropylamine → 1-[(Propan-2-yl)amino]-3-[(1,3-thiazol-2-yl)oxy]propan-2-ol

HRID 1576677Notes

Reaction equation

HRID 1576677 reaction equation
[CH:1]([NH2:4])([CH3:3])[CH3:2].[O:5]1[CH:7]([CH2:8][O:9][C:10]2[S:11][CH:12]=[CH:13][N:14]=2)[CH2:6]1>C(O)C>[CH:1]([NH:4][CH2:6][CH:7]([OH:5])[CH2:8][O:9][C:10]1[S:11][CH:12]=[CH:13][N:14]=1)([CH3:3])[CH3:2]

Participants

4

Reactant 2

HCID 6363IsopropylamineHCID 12399817HCID 12399817, compound2×

Product 1

HCID 717211-[(Propan-2-yl)amino]-3-[(1,3-thiazol-2-yl)oxy]propan-2-ol

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

This example illustrates further methods according to the invention of preparing the compounds of formula I of the invention. In this example 0.6 g. of isopropyl amine is added to a solution of 0.3 g. of 1,2-epoxy-3-(thiazol-2-oxy)-propane in 20 ml. of anhydrous absolute ethanol at 20°C. The resulting mixture is monitored by thin-layer chromatographic analysis and allowed to stand until conversion of 1,2-epoxy-3-(thiazol-2-oxy)-propane is essentially complete. The mixture is then evaporated to dryness yielding a crude residue of 1-isopropylamino-3-(thiazol-2-oxy)-2-propanol which is then further purified by thin-layer chromatography.

Workup

  1. customaccording to the invention of preparing the compounds of formula I of the invention
  2. customat 20°C
  3. customThe mixture is then evaporated to dryness

Sources & evidence

ORD record
ord-0d674260845440b18a9093b926de04c3
Source dataset
uspto-grants-1976_09
Patent number
US03982010

Reaction notes

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