Morpholine → HCID 86734017, compound

HRID 1576678Notes

Reaction equation

HRID 1576678 reaction equation
[NH:1]1[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.[O:7]1[CH:9]([CH2:10][O:11][C:12]2[S:13][CH:14]=[CH:15][N:16]=2)[CH2:8]1>C(O)C>[O:4]1[CH2:5][CH2:6][N:1]([N:16]2[CH:15]=[CH:14][S:13][CH:12]2[O:11][CH2:10][CH:9]([OH:7])[CH3:8])[CH2:2][CH2:3]1

Participants

4

Reactant 2

HCID 8083MorpholineHCID 12399817HCID 12399817, compound2×

Product 1

HCID 86734017HCID 86734017, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

This example illustrates further methods according to the invention of preparing the compounds of formula I of the invention. In this example 1 g. of morpholine is added to a solution of 0.3 g. of 1,2-epoxy-3-(thiazol-2-oxy)-propane in 20 ml. of anhydrous absolute ethanol at 20°C. The resulting mixture is monitored by thin-layer chromatographic analysis and allowed to stand until conversion of 1,2-epoxy-3-(thiazol-2-oxy)-propane is essentially complete. The mixture is then evaporated to dryness yielding a crude residue of 1-(N-morpholino-3-(thiazol-2-oxy)-2-propanol which is then further purified by thin-layer chromatography.

Workup

  1. customaccording to the invention of preparing the compounds of formula I of the invention
  2. customat 20°C
  3. customThe mixture is then evaporated to dryness

Sources & evidence

ORD record
ord-857cf0b62be1473aa46d7ee3fd8e84a5
Source dataset
uspto-grants-1976_09
Patent number
US03982010

Reaction notes

Loading…