Ethanolamine → HCID 21511657, compound

HRID 1576679Notes

Reaction equation

HRID 1576679 reaction equation
[CH2:1]([CH2:3][NH2:4])[OH:2].[O:5]1[CH:7]([CH2:8][O:9][C:10]2[S:11][CH:12]=[CH:13][N:14]=2)[CH2:6]1>C(O)C>[OH:2][CH2:1][CH2:3][NH:4][CH2:6][CH:7]([OH:5])[CH2:8][O:9][C:10]1[S:11][CH:12]=[CH:13][N:14]=1

Participants

4

Reactant 2

HCID 700EthanolamineHCID 12399817HCID 12399817, compound2×

Product 1

HCID 21511657HCID 21511657, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

This example illustrates further methods according to the invention of preparing the compounds of formula I of the invention. In this example 0.6 g. of ethanolamine is added to a solution of 0.3 g. of 1,2-epoxy-3-(thiazol-2-oxy)-propane in 20 ml. of anhydrous absolute ethanol at 20°C. The resulting mixture is monitored by thin-layer chromatographic analysis and allowed to stand until conversion of 1,2-epoxy-3-(thiazol-2-oxy)-propane is essentially complete. The mixture is then evaporated to dryness yielding a crude residue of 1-(β-hydroxyethylamino)-3-(thiazol-2-oxy)-2-propanol which is then further purified by thin-layer chromatography.

Workup

  1. customaccording to the invention of preparing the compounds of formula I of the invention
  2. customat 20°C
  3. customThe mixture is then evaporated to dryness

Sources & evidence

ORD record
ord-fce3a532582a476aa3728e1f71499981
Source dataset
uspto-grants-1976_09
Patent number
US03982010

Reaction notes

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