Sodium Hydroxide → HCID 54129660, compound

HRID 1576720Notes

Reaction equation

HRID 1576720 reaction equation
C([NH:4][C:5]1[CH:34]=[CH:33][C:8]([O:9][C:10]2[C:18]([S:19](=[O:25])(=[O:24])[NH:20]C(=O)C)=[CH:17][C:13]([C:14]([OH:16])=[O:15])=[CH:12][C:11]=2[NH:26][CH2:27][C:28]2[O:32][CH:31]=[CH:30][CH:29]=2)=[CH:7][CH:6]=1)(=O)C.[OH-].[Na+]>>[NH2:4][C:5]1[CH:6]=[CH:7][C:8]([O:9][C:10]2[C:18]([S:19](=[O:24])(=[O:25])[NH2:20])=[CH:17][C:13]([C:14]([OH:16])=[O:15])=[CH:12][C:11]=2[NH:26][CH2:27][C:28]2[O:32][CH:31]=[CH:30][CH:29]=2)=[CH:33][CH:34]=1

Participants

3

Reactant 2

HCID 14798Sodium HydroxideHCID 54348889HCID 54348889, compound

Product 1

HCID 54129660HCID 54129660, compound

Procedure

The mixture of 1.1 g of 4-(4-acetamidophenoxy)-3-furfurylamino-5-acetylsulfamoylbenzoic acid and 11 ml of 2N aqueous sodium hydroxide is refluxed for 2 hours under nitrogen. After cooling to room temperature it is filtered, the filtrate acidified with glacial acetic acid to a pH of 4-5 and the precipitate formed filtered off. It is recrystallized from 70% aqueous ethanol, to yield the 4-(4-aminophenoxy)-3-furfurylamino-5-sulfamoylbenzoic acid melting at 233°-235°.

Workup

  1. temperatureis refluxed for 2 hours under nitrogen
  2. filtrationis filtered
  3. customthe precipitate formed
  4. filtrationfiltered off
  5. customIt is recrystallized from 70% aqueous ethanol

Sources & evidence

ORD record
ord-4510de74dfe84ab7a52c4a3ac078daa5
Source dataset
uspto-grants-1976_09
Patent number
US03982018

Reaction notes

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