HCID 54418976, compound → HCID 53964910, compound

Participants

Reaction Steps

The mixture of 2 g of 4-(4-acetamidophenylmercapto)-3-(2-methylallylamino)-5-sulfamoylbenzoic acid and 20 ml of 2 N aqueous sodium hydroxide is refluxed for 1 hour under nitrogen. After cooling it is filtered and the filtrate acidified with acetic acid to a pH of 4-5. The precipitate formed is filtered off and recrystallized from aqueous ethanol, to yield the 4-(4-aminophenylmercapto)-3-(2-methylallylamino)-5-sulfamoylbenzoic acid melting at 237°-240°.

Provenance & Evidence